Estriol Face Cream for Wrinkles in the Perimenopause and Menopause

Estriol face cream works in several ways, including reducing wrinkles through collagen stimulation, improving skin healing capacity, repairing skin barrier function, and decreasing inflammation.

• One of oestrogen’s crucial functions is enhancing collagen synthesis, which is the skin’s foundational support structure. Collagen is essential for maintaining skin thickness and elasticity. However, as both men and women age, collagen production decreases, leading to facial wrinkles and sagging skin.
• Oestrogen-deficient skin has impaired barrier function, increasing dryness, itchiness, and sensitivity and contributing to inflammaging.

The estriol face cream prescribed by Dr Aishah is formulated explicitly with ceramide-rich barrier repair cream.

Significant hormonal shifts characterise the transition between perimenopause, menopause, and postmenopause. As oestrogen levels decline in our 40s, 50s, and beyond, many women experience dramatic transformations in their skin, including wrinkles.

• Research indicates that collagen loses nearly 30% within the first five years of menopause. This decline often manifests in signs such as dryness, increased sensitivity, loss of firmness, dull, thinning, crepey skin, and increased wrinkles and sagging.
• Studies have shown that oestrogen cream helps wrinkles by impacting the skin’s structural changes caused by hormone deficiencies. It addresses the core changes in your skin.
• Estriol cream’s action goes beyond wrinkles. No matter what treatment you receive, the response will likely be suboptimal if the fundamental deficiency remains unaddressed.

Dr Aishah is keen to understand how the skin evolves through the different stages of menopause. She aims to provide tailored skincare solutions that meet your skin’s unique needs, help address wrinkles, and restore skin health.

Estriol face cream can be fundamental in restoring oestrogen levels and enhancing the ability to produce collagen. Studies show that estriol face cream effectively plumps the skin and helps it retain a youthful appearance. The skin is an oestrogen-responsive endocrine tissue, and without oestrogen’s growth-promoting effects, the skin can become significantly thinner.

Falling hormone levels play a significant role in intrinsic ageing changes in both men and women; however, this is not the complete picture. Other changes occur due to intrinsic ageing factors, such as decreased mitochondrial function, accumulation of senescent cells, toxic protein waste products, changes to the skin microbiome, and chronic inflammageing. These cellular and molecular changes are known as the hallmarks of ageing. They occur in all cells in your body. Interestingly, oestrogen is known to affect most of the 12 hallmarks of ageing.

Other changes occur due to extrinsic ageing factors. These include D.N.A. damage from sun exposure and pollution, altered epigenetic expression due to stress, poor sleep, excessive alcohol, poor diet choices, and glycation (A.G.E. formation) from excess sugar and simple carbs. Taking a holistic view of skin ageing and wrinkle formation is essential. So, though estriol face cream can be foundational in addressing things like wrinkles, it is one piece of the puzzle.

Dr Aishah takes a holistic approach and will not merely assess your suitability for Estriol face cream to treat your wrinkles. Because of her interest in weight training, she has in-depth knowledge of nutrition and exercise’s impact on health (including your skin)

It’s important to note that “oestrogen” encompasses four different hormones: oestrogen (E1), estradiol (E2), and estriol (E3). When people refer to oestrogen, they usually mean estradiol (E2), which accounts for about 80% of oestrogen levels during a woman’s reproductive years (from puberty to pre-menopause). Estriol (E3) represents roughly 10%, while Estrone (E1) accounts for the remaining 10%.

Estriol (E3) is considered a weaker form of oestrogen. Unlike other oestrogens, topical estriol does not require balancing with progesterone and does not produce systemic effects on the body. This makes estriol an ideal candidate for topical applications, as research suggests its effects are localised to the skin rather than affecting the bloodstream. However, you need a full consultation with Dr Aishah to assess your skin and general medical health. You may need blood and a women’s check. She can work alongside your menopause doctor or general practitioner.

Estriol face cream is suitable for women who want to enhance their skin’s appearance and health. It can boost collagen development, increase skin elasticity and moisture levels, repair the skin barrier, and reduce the appearance of wrinkles. However, there can be contraindications to its use, and it is important to consult with Dr Aishah, who will assess not only your suitability for estriol face cream for wrinkles but also advise on all issues related to menopausal skin changes.

Topical estriol face cream is safe and effective in preventing skin changes associated with menopause. As new studies emerge, the potential benefits of incorporating estriol face cream into skincare routines for menopausal individuals continue to look promising. There is evidence of the impact of estriol cream on the healing of chronic ulcers in men and women, as well as the use of phytoestrogens.

1. Rzepecki, A. K., Murase, J. E., Juran, R., Fabi, S. G., & McLellan, B. N. (2019). Estrogen-deficient skin: The role of topical therapy. International journal of women’s dermatology, 5(2), 85–90. https://doi.org/10.1016/j.ijwd.2019.01.001
2. Lephart, E. D., & Naftolin, F. (2022). Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs). Clinical, cosmetic and investigational dermatology, 15, 1695–1709. https://doi.org/10.2147/CCID.S333663
3. https://www.youtube.com/watch?v=7sqtzYw-vcQ
4. Zomer, H. D., & Cooke, P. S. (2023). Targeting estrogen signaling and biosynthesis for aged skin repair. Frontiers in physiology, 14, 1281071. https://doi.org/10.3389/fphys.2023.1281071
5. Lephart ED. Resveratrol, 4′ Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health. Int J Mol Sci. 2017 Jun 3;18(6):1193. doi: 10.3390/ijms18061193. PMID: 28587197; PMCID: PMC5486016.
6. Rispo, F., De Negri Atanasio, G., Demori, I., Costa, G., Marchese, E., Perera-Del-Rosario, S., Serrano-Candelas, E., Palomino-Schätzlein, M., Perata, E., Robino, F., Ferrari, P. F., Ferrando, S., Letasiova, S., Markus, J., Zanotti-Russo, M., & Grasselli, E. (2024). An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology. Frontiers in cell and developmental biology, 11, 1305835. https://doi.org/10.3389/fcell.2023.1305835
7. Sun, M., Deng, Y., Cao, X., Xiao, L., Ding, Q., Luo, F., Huang, P., Gao, Y., Liu, M., & Zhao, H. (2021). Effects of Natural Polyphenols on Skin and Hair Health: A Review. Molecules, 27(22), 7832. https://doi.org/10.3390/molecules27227832